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Coenzyme Q10 Supplementation and Potential Benefits in Male Fertility

At a Glance: Coenzyme Q10 (ubiquinone) supplementation was recently shown to improve the health and energy characteristics of sperm in men with unexplained infertility.

Previous research has shown that Coenzyme Q10 is present in measurable levels in human seminal fluid, where it most likely exerts important metabolic and antioxidant functions.

In a paper published in a recent edition of Fertility and Sterility, researchers evaluated the effectiveness of CoQ10 treatment in improving semen quality in men with idiopathic infertility. Idiopathic infertility is defined as infertility without a defined or known cause.

The placebo-controlled, double-blind randomized trial included 60 male infertility patients aged 27-39 years. The participants took either 200 mg/day of CoQ10 (ubiquinone) or a placebo for six months, with three months of follow-up.

Coenzyme Q10 and ubiquinol increased significantly in both seminal plasma and sperm cells after treatment, as well as increasing sperm motility. Patients with lower baseline values of sperm motility and CoQ10 levels had a greater likelihood of responding positively to the treatment.

Coenzyme Q10 supplementation increases the level of ubiquinone and ubiquinol in semen and is effective in improving sperm motility in patients affected by unexplained infertility.

Fertil Steril 2009 May;91(5):1785-92

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